Megatons are extremely tanky and dangerous enemies, dealing massive amounts of damage with any of their attacks. As soon as one spawns, they should be the priority, focusing fire on their head within the hazmat suit to deal critical damage to them. Once the Megaton's health is depleted, it will split into two forms, Megaton Bomber and Megaton Blaster, each having one of the radioactive attacks while both maintain the melee strength of the combined form.

The Megaton Bomber has the singular Radioactive Blast, while the Megaton Blaster has the Radioactive Flurry attack. These split forms are much faster than the combined form while having less health, but the same potency. These enemies can be burned down extremely quickly with critical shots due to their reduced health, but remain a constant threat until taken down.