Blightfathers have a lot of health and deal significant damage in close range. They are slightly weak to explosive damage, so the Hellion Salvo rocket launcher is extremely effective against them, and it can home in on the weak points on their back and elbows.

Special Weapons are also extremely effective against the Blightfather; however, be careful when using extremely close-range ones like the Hammer of Valhalla and Chakrams of Vengeance, as the Blightfather can quickly take down a player in close range by spamming its melee attack. Instead, opt for something like the Viper and Dragon.