In Origins, the Panzersoldat is only equipped with the Flamethrower and Giant Claw, whereas in both Der Eisendrache and Revelations, the Panzersoldat is equipped with the EMP Cannon instead of the Giant Claw. The weak points remain the same between the three maps, with the main weak point being the yellow glowing Power Core on its chest and the secondary weak point being its Head.

In Origins, the Ray Gun MKII is available from the box and is extremely effective against the Panzersoldat as well as any of the four upgraded staves. In Der Eisendrache, any Pack-a-Punched shotgun or upgraded bow is extremely effective against the Panzersoldat. In Revelations, the Thundergun and Apothican Servant are extremely effective against the Panzersoldat.